FIRST-IN-CLASS SUPERIOR MAST CELL THERAPEUTICS
FROM NOVEL DISCOVERED BIOLOGY TO SUPERIOR THERAPEUTICS
Discovery of a novel mast cell target that is designed by nature to control and regulate the entire mast cell activity.
Superior Therapeutic Profile
Superior Therapeutic Efficacy with complete silencing of selectively dysfunctional and activated mast cells with therapeutic efficacy on all
disease-driving pathways (independent of the activation trigger).
Excellent Safety as only activated mast cells that are disease-driving are selectively targeted resulting in no immune-suppressive side effects.
Broad Therapeutic and Multi-Symptom Treatment of multiple diseases and related symptoms (e.g. skin, gastrointestinal, lung) with ability to target mast cells in all organs with similar dosing.
Potentially Disease-Modifying reversing disease progress over time (“turning back the disease clock”) by reduction of accumulated mast cells.
In-human validated pharmacology and corresponding human ex-vivo and
in-vivo model validation with expected high probability for clinical success.
drug development and pipeline
Lead Program Small Molecules
Small molecule MCS111/2-XXX with currently two lead program series (MCS111XX, MCS112XX) with expected excellent translation to clinical success in humans targeting major disease areas in dermatology (e.g. chronic spontaneous urticaria), rare disease systemic mastocytosis, respiratory (COPD, asthma), gastrointestinal diseases (food allergy, IBS, IBD), fibrotic diseases (pulmonary fibrosis, liver fibrosis), and systemic chronic inflammation disorders (e.g. MCAS, chronic lyme, fibromyalgia, long covid).
Follow-Up Program mAb
MCS20-XXX Series designed to enable enhanced mast cell silencing and depletion for the accelerated depletion of accumulated activated mast cells in a controlled manner to meet specific disease needs, for example, in fibrotic diseases, COPD and rare disease systemic mastocytosis.
Follow-Up Program Small Molecules Neuroinflammation
MCS12-XXX Series targeting mast cells in neuroinflammation in diseases such as ASD (autism spectrum disorders), ALS, severe dengue, stroke, alzheimer’s disease and mood disorders.
